• 作者：Rocí ; o Gonzá ; lez Leó ; n ; Marí ; a Jesú ; s Castillo Palma ; Francisco José ; Garcí ; a Herná ; ndez ; Julio Sá ; nchez Romá ; n ; ^{julio.sanchez.sspa@juntadeandalucia.es} ; ^{sanchezroman@telefonica.net}
• 关键词：Lupus eritematoso sisté ; mico ; Infecciones ; Autoinmunidad
• 刊名：Medicina Cl铆nica
• 出版年：2010
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：11 September 2010
• 卷：135
• 期：8
• 页码：365-367
• 文件大小：122 K

Background and objective

To study severe infectious complications in a cohort of patients with systemic lupus erythematosus (SLE).

Patients and method

Retrospective study of 705 patients followed from January 1980 to January 2008. Data are expressed in percentages.

Results

The frequency of severe infectious was 38,6%. The etiology was bacterial 54,4%, viric 30,4%and opportunist in 15,2%patients. Involved organs were: Lung 38,2%, kidney 48,9%, central nervous system 43%. 43,75%patients received pulsed ciclofosfamide therapy and 88,6%received glucocorticoids (39,7%pulsed). The mortality was 27,7%.

Conclusions

At present, infection is an important cause of mortality in patients with SLE. Early diagnosis of infectious complications is very important in SLE.