Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians

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• 作者：Dingyan Chen^a ; ¹ ; Li Liu^a ; ¹ ; Yang Xiao^a ; Yuehua Peng^a ; Chengwu Yang^b ; Zengzhen Wang^a ; ^{wzzh@mails.tjmu.edu.cn}
• 关键词：Opioid receptors ; Mu-opioid receptor gene ; Alcohol dependence ; Alcoholism ; Meta-analyses
• 刊名：Drug and Alcohol Dependence
• 出版年：2012
• 期刊代码：81_03768716
• 类别：med
• 出版时间：1 June, 2012
• 卷：123
• 期：1-3
• 页码：1-6
• 文件大小：453 K

摘要

Background

Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted.

Methods

We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate.

Results

Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95%confidence interval [CI], 1.33-2.25; GA + GG vs. AA: OR, 1.57; 95%CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95%CI, 0.75-1.49; GA + GG vs. AA: OR, 1.11; 95%CI, 0.79-1.55).

Conclusions

The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.