Physical activity and decreased risk of clinical gallstone disease among post-menopausal women

详细信息	查看全文 | 推荐本文 |

• 作者：Kristi L. Storti ; Jennifer S. Brach ; Shannon J. FitzGerald ; Joseph M. Zmuda ; Jane A. Cauley and Andrea M. Kriska
• 刊名：Preventive Medicine
• 出版年：2005
• 期刊代码：306_00917435
• 类别：med
• 出版时间：2005
• 卷：41
• 期：3-4
• 页码：772-777
• 文件大小：102 K

摘要

Background.

Physical activity may play a role in preventing gallstone disease.

Methods.

The activity/gallstone relationship was examined in post-menopausal women from the Study of Osteoporotic Fractures (SOF; 1986–1988), a prospective study of fracture risk factors in 8010 women (mean age = 71.1 years, SD = 4.9).

Results.

Multivariate logistic regression indicated women in the lowest two quartiles of physical activity, according to questionnaire, had a 59%{OR = 1.59 (1.11–2.29), P = 0.02} and a 57%higher risk {OR = 1.57 (1.11–2.23), P = 0.01} of developing gallstone disease compared to women in the highest quartile of activity (P_Trend = <0.0001). Additionally, this relationship was examined in a cohort of 182 post-menopausal women (mean age 74.2 years, SD = 4.1) who participated in a randomized controlled trial of a walking intervention. Women in the randomized clinical trial in the lowest tertile of physical activity determined by a physical activity monitor had a higher risk of developing gallstone disease than women in the highest tertile of physical activity, 13%{OR-1.13 (1.01–1.28), P = 0.05, P_Trend = <0.04}.

Conclusion.

Physical activity appears to be inversely related to the development of gallstone disease in post-menopausal women independent of body mass index.