- 作者：Guillaume Lehé ; ricey<sup>1sup><sup> ; sup><sup>2sup> ; Nadine Le Forestier<sup>2sup><sup> ; sup><sup>3sup><sup> ; sup><sup>4sup> ; Luc Dupuis<sup>5sup> ; Jé ; sus Gonzalez-Bermejo<sup>2sup><sup> ; sup><sup>6sup> ; Vincent Meininger<sup>2sup><sup> ; sup><sup>3sup> ; Pierre-Franç ; ois Pradat<sup>2sup><sup> ; sup><sup>3sup><sup> ; sup><sup>7sup><sup> ; sup><sup>pierre-francois.pradat@psl.aphp.frsup>
- 刊名：La Presse M¨|dicale
- 出版年：2012
- 期刊代码：pca289_07554982
- 类别：med
- 出版时间：June, 2012
- 卷：41
- 期：6_part_P1
- 页码：560-574
- 文件大小：370 K
ss="h3">Key points
<strong class="boldFont">Malnutrition and dehydration are commonstrong> and result from <strong class="boldFont">swallowing disordersstrong> secondary to degeneration of brainstem motor neurons.Recent knowledge argues in favor of the associated <strong class="boldFont">primary metabolism abnormalitiesstrong>. Though muscle atrophy, a paradoxical <strong class="boldFont">hypermetabolism at reststrong> has often been observed. <strong class="boldFont">Hyperlipidemia and glucose intolerancestrong> are more frequent than in general population.
The heterogeneity of the <strong class="boldFont">nutritional assessmentstrong> of patients in published series is due, partially at least, to the use of disparate criteria and evaluating procedures. <strong class="boldFont">Weight loststrong> is an independent negative survival prognostic factor. <strong class="boldFont">Overweightstrong> may be beneficial for the survival of ALS patients.
<strong class="boldFont">A specific nutritional management for ALSstrong> is an essential point in the multidisciplinary support. <strong class="boldFont">The criteria leading to artificial nutritionstrong> indication are medical, mainly based on percentage of weight loss, but also psychological and ethical.