The role of CCR7 in allergic airway inflammation induced by house dust mite exposure

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• 作者：Masaki Kawakami^a ; ^b ; Osamu Narumoto^a ; ^b ; Yukiko Matsuo^a ; Kazuhide Horiguchi^c ; Satomi Horiguchi^c ; Naohide Yamashita^d ; Masahiro Sakaguchi^e ; Martin Lipp^f ; Takahide Nagase^b ; Naomi Yamashita^a ; ^{naoyama@musashino-u.ac.jp}
• 关键词：HDM ; house dust mite ; CCR7KO ; CCR7-knockout ; LPS ; lipopolysaccharide ; BALF ; bronchoalveolar lavage fluid ; HE ; haematoxylin-eosin ; PAS ; periodic acid-Schiff ; iBALT ; inducible bronchus-associated lymphoid tissue ; HMGB ; high-mobility group box ; Treg ; regulat
• 刊名：Cellular Immunology
• 出版年：2012
• 期刊代码：279_00088749
• 类别：med
• 出版时间：January-February, 2012
• 卷：275
• 期：1-2
• 页码：24-32
• 文件大小：1432 K

摘要

House dust mite (HDM), the most common allergen, activate both the IgE-associated and innate immune responses. To clarify the process of sensitization, we investigated the role of the CCL21, CCL19, and CCR7 axis in a mouse model of HDM-induced allergic asthma. HDM inhalation without systemic immunization resulted in a HDM-specific IgE response. CCR7-knockout (CCR7KO) mice exhibited greater airway inflammation and IgE responses compared to wild-type mice. We examined FoxP3 expression in these mice to clarify the contribution of regulatory cells to the responses. FoxP3 expression was higher in the lungs but not in the lymph nodes of CCR7KO mice compared to wild-type mice. In CCR7KO mice, FoxP3-positive cells were found in lung, but we observed higher release of IL-13, IL-5, TGF-尾, IL-17, and HMGB1 in bronchoalveolar lavage fluid. We demonstrate here that immuno-regulation through CCR7 expression in T cells plays a role in HDM-specific sensitization in the airway.