Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals

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• 作者：Benedikt Fritzsching ; Mirjam Korporal ; Jü ; rgen Haas ; Peter H. Krammer ; Elisabeth Suri-Payer ; Brigitte Wildemann
• 关键词：Multiple sclerosis ; Regulatory T cells ; Autoimmunity ; Apoptosis ; CD95
• 刊名：Journal of the Neurological Sciences
• 出版年：2006
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：21 December 2006
• 卷：251
• 期：1-2
• 页码：91-97
• 文件大小：413 K

摘要

Impaired suppressive function of CD4⁺CD25^high regulatory T cells (T_reg) has been reported as a novel pathogenetic mechanism in Multiple sclerosis (MS). We addressed if high apoptosis sensitivity of MS-T_reg could explain this functional T_reg defect. T_reg from treatment-naïve MS patients showed high sensitivity towards CD95Ligand-mediated apoptosis and exhibited enhanced cell death to IL-2 and TCR-signal deprivation. Since susceptibility of T_reg to cell death was similar in MS patients and healthy controls, this cannot explain the inhibitory dysfunction of T_reg associated with MS. Furthermore, as cell death is not enhanced, therapeutic expansion of MS-T_reg in vitro should be a reasonable and novel therapeutic option.