Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports

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• 作者：Daniel C. Lu ; Devin K. Binder ; Bonnie Chien ; Alan Maisel ; Geoffrey T. Manley
• 关键词：Brain natriuretic peptide ; Traumatic brain injury ; Cerebral salt-wasting syndrome
• 刊名：Surgical Neurology
• 出版年：2008
• 期刊代码：244_00903019
• 类别：med
• 出版时间：March 2008
• 卷：69
• 期：3
• 页码：226-229
• 文件大小：275 K

摘要

Historically, hyponatremia in patients with varying brain diseases was termed cerebral salt wasting. Hyponatremia secondary to CSW was reported to be a distinct entity from SIADH, with the distinguishing feature of decreased extracellular fluid volume. Brain natriuretic peptide, a peptide with natriuretic, vasorelaxant, and aldosterone-inhibiting properties, was recently implicated in aneurysmal SAH patients with CSW. Here, we describe 2 cases of CSW in TBI patients with elevated BNP levels. This phenomenon has not been previously described.