- 作者：Uchikova ; Ekaterina H. ; Ledjev ; Ilija I.
- 刊名：European Journal of Obstetrics and Gynecology
- 出版年：2005
- 期刊代码：92_03012115
- 类别：med
- 出版时间：April 1, 2005
- 卷：119
- 期：2
- 页码：185-188
- 文件大小：92.2 K
Objectives:(1) To study the changes in the haemostatic variables during normal pregnancy, and (2) to compare them with the corresponding variables in a control group of nonpregnant women.Setting:
University Hospital.
Subjects:
The study involves two groups of women: pregnant women (in 35th–40th gestational weeks (GW)) (N = 35) and a control group of nonpregnant women (N = 35).
Methods:
We examined the global tests, the variables relating to coagulation and fibrinolysis and the group of natural inhibitors of coagulation, and compared them between the two groups.
Results:
The pregnant women had statistically significantly higher values for: prothrombin time (PT) (P < 0.0001), thrombin time (TT) (P < 0.0001), fibrinogen (P < 0.0001), activity of factor VII (P < 0.0001), factor X (P < 0.0001) and alpha2-antiplasmin (P < 0.002), plasma concentration of d-dimer (plsDD) (P < 0.0001) and activity of heparin cofactor II (HCII) (P < 0.002). They had statistically significantly lower activity of protein C (PrC) (P < 0.0001) and of total protein S (TPrS) (P < 0.0001).
Conclusion:
During normal pregnancy the activation of coagulation is counterbalanced by the activation of fibrinolysis, which maintains the haemostatic balance.