Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities

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• 作者：Jun-Cheol Cho^a ; Ho Sik Rho^b ; ^{thiocarbon@freechal.com} ; Yung Hyup Joo^b ; Chang Seok Lee^b ; Jaekyoung Lee^b ; Soo Mi Ahn^c ; Jung Eun Kim^d ; Song Seok Shin^b ; Young-Ho Park^b ; Kyung-Do Suh^a ; Soo Nam Park^d ; ^{snpark@seoultech.ac.kr}
• 关键词：Depigmentation ; Tyrosinase ; Hydroxylbenzoic acid ; Kojic acid
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 June, 2012
• 卷：22
• 期：12
• 页码：4159-4162
• 文件大小：279 K

摘要

We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.