Exercise training improves the antioxidant enzyme activity with no changes of telomere length
- 作者：Yun-A. Shin ; Jun-Hyoup Lee ; Wook Song ; Tae-Won Jun
- 关键词：Telomere length ; Oxidative stress ; Antioxidant enzyme activity ; Long-term exercise training ; Acute exercise test
- 刊名：Mechanisms of Ageing and Development
- 出版年：2008
- 期刊代码：193_00476374
- 类别：med
- 出版时间：May 2008
- 卷：129
- 期：5
- 页码：254-260
- 文件大小：205 K
摘要
The purpose of this study was to determine the changes of both oxidant and antioxidant levels with exercise training in obese middle-aged women. The association between telomere length and oxidative stress with exercise was also examined. Sixteen obese middle-aged women participated in this study. The subjects were randomly divided into exercise group (EX) and control group (CON). EX performed aerobic exercise training for 6 months. DNA was extracted from leukocytes in peripheral blood and their telomere lengths were measured by real time PCR analysis. Long-term exercise training decreased body weight and BMI, and increased name="mml7">
. Resting levels of erythrocyte glutathione peroxidase activity were higher in EX compared to CON. Superoxide dismutase (SOD) activities were higher after the acute exercise test at mid-intensity in post-exercise training than in the pre-exercise training conditions. The telomere length did not change significantly after the acute exercise test in the pre-exercise training condition in spite of the increased level of malondialdehyde (MDA) as a marker of oxidative stress. In conclusion, antioxidant enzyme activities were increased following long-term exercise training; however, the lengths of telomere in leukocytes were not influenced by both mid-intensity and high intensity of exercise stress.