A convenient synthesis of 6,6′-dimethyl-2,2′-bipyridine-4-ester and its application to the preparation of bifunctional lanthanide chelators
- 作者：Fabien Havas ; Mathieu Danel ; Chantal Galaup ; Pierre Tisnè ; s ; Claude Picard
- 关键词：Bipyridine ; Bifunctional chelators ; Lanthanides
- 刊名：Tetrahedron Letters
- 出版年：2007
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：5 February 2007
- 卷：48
- 期：6
- 页码：999-1002
- 文件大小：143 K
摘要
We describe a convenient scalable synthesis of 4-carbomethoxy-6,6′-dimethyl-2,2′-bipyridine based on the application of modified Negishi cross-coupling conditions. The use of this building block in the preparation of a number of dissymmetrically 6,6′-trisubstituted-2,2′-bipyridines and of bifunctional lanthanide chelators is also reported.