Analysis of herbal dietary supplements for sexual performance enhancement: First characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants
- 作者：Sté ; phane Balayssac ; Vé ; ronique Gilard ; Chantal Zedde ; Robert Martino ; Myriam Malet-Martino ; martino@chimie.ups-tlse.fr
- 关键词：Dietary supplements ; Adulterants ; Propoxyphenyl-thiohydroxyhomosildenafil ; NMR ; MS
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2012
- 期刊代码：65_07317085
- 类别：ch
- 出版时间：7 April, 2012
- 卷：63
- 期：Complete
- 页码：135-150
- 文件大小：1047 K
摘要
Nine herbal dietary supplements intended to be beverages for enhancing sexual performance were analyzed before their possible launch on the market. Four of them contained a sildenafil analog reported for the first time as an adulterant. After isolation and characterization using NMR, MS, IR and UV, this analog was named propoxyphenyl-thiohydroxyhomosildenafil as the ethoxy chain on the phenyl ring of the already known analog thiohydroxyhomosildenafil was replaced by a propoxy moiety. One formulation was tainted with thiosildenafil, another unapproved PDE-5 inhibitor. Sildenafil along with the natural alkaloid tetrahydropalmatine that has no documented effect for enhancing erectile dysfunction were identified in two formulations. Another formulation was adulterated with phentolamine, a drug that is not approved for boosting male sexual performance when taken orally. The last formulation containing osthole, a bioactive natural coumarine improving sexual dysfunction, is most probably truly natural.