Origin of non-cardiac endothelial cells from an Isl1+ lineage

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• 作者：Iain D. Keenan ; Hong Jun Rhee ; Bill Chaudhry ; Deborah J. Henderson ; ^{deborah.henderson@ncl.ac.uk}
• 关键词：Endothelium ; Isl1 ; Lineage tracing ; Systemic vasculature ; Umbilical vasculature ; Rac1
• 刊名：FEBS Letters
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：21 June, 2012
• 卷：586
• 期：13
• 页码：1790-1794
• 文件大小：1465 K

摘要

The cardiovascular system consists of many cell types with distinct embryonic origins. Cells from an Islet1 (Isl1)-expressing progenitor population make a substantial contribution to the developing heart. We reasoned that cells derived from Isl1-expressing progenitors might contribute more widely to the cardiovascular system. We show that cells derived from an Isl1-expressing progenitor lineage make a wide contribution to the systemic vasculature and that embryos conditionally deficient for Rac1 within this cell population develop defects in the non-cardiac vasculature. These data define new roles for Isl1 in the developing embryo and demonstrate a contribution of Isl1-expressing progenitors to vascular endothelium in vivo.