Antioxidant/pro-oxidant properties of model phenolic compounds. Part II: Studies on mixtures of polyphenols at different molar ratios by chemiluminescence and LC-MS

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• 作者：Lamis Choueiri^a ; ¹ ; Veronica Sanda Chedea^b ; Antony Calokerinos^c ; Panagiotis Kefalas^a ; ^{panos@maich.gr}
• 关键词：CA ; caffeic acid ; Q ; quercetin ; AA ; ascorbic acid ; Cat ; catechin ; EDTA ; ethylenediamine tetraacetic acid ; Io ; chemiluminescence intensity at the absence of antioxidant ; IC50 ; concentration of compound ; which is required to decrease Io intensity by 50% ; RO
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：1 August, 2012
• 卷：133
• 期：3
• 页码：1039-1044
• 文件大小：517 K

摘要

The behaviour of four known antioxidants (quercetin, ascorbic acid, catechin and caffeic acid) and their mixtures at different molar ratios was studied in view of elaborating predictions over an eventual pro-oxidant or synergistic antioxidant activity. The Co(II)-EDTA luminol chemiluminescence showed that the mixture of quercetin and ascorbic acid at ratio 2:1 had the most pronounced antioxidant activity, while that of quercetin and caffeic acid at ratio 1:2 showed the least antioxidant activity, which may be interpreted as a strong propensity for pro-oxidant behaviour. The LC-MS analysis for the two mixtures revealed a significant amount of unoxidised quercetin in the case of quercetin with ascorbic acid, whereas in the case of quercetin with caffeic acid this amount was negligible. This observation supports the fact that the first combination was more antioxidant than the second, through efficient quercetin recycling (reduction of the quinone by ascorbic acid; redox cycling of quinones).