Single-nucleotide polymorphisms in inflammatory bowel disease

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• 作者：Manuela G. Neuman ; ^{manuela.neuman@utoronto.ca} ; Radu M. Nanau
• 关键词：ATG16L1 ; autophagy gene autophagy-related 16-like 1 ; BPI ; bactericidal permeability-increasing protein ; CAG ; haplotype A ; CARD ; caspase recruitment domain family ; CCL2 ; chemokine C-C motif ligand 2 ; CCNY ; cyclin y ; CD ; Crohn disease ; CXCR3 ; chemokine (C-X
• 刊名：Translational Research
• 出版年：2012
• 期刊代码：340_19315244
• 类别：med
• 出版时间：July, 2012
• 卷：160
• 期：1
• 页码：45-64
• 文件大小：179 K

摘要

Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental factors play important roles. This review discusses several single-nucleotide polymorphisms with either susceptibility or protective effects on inflammatory bowel disease.