Sequential versus concurrent anthracyclines and taxanes as adjuvant chemotherapy of early breast cancer: A meta-analysis of phase III randomized control trials

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• 作者：Nan Shao^a ; Shenming Wang^a ; Chen Yao^a ; Xiangdong Xu^a ; Yunjian Zhang^a ; Yuanyuan Zhang^b ; Ying Lin^a ; ^{frostlin@hotmail.com}
• 关键词：Early breast cancer ; Adjuvant chemotherapy ; Sequential ; Concurrent ; Meta-analysis
• 刊名：The Breast
• 出版年：2012
• 期刊代码：321_09609776
• 类别：med
• 出版时间：June, 2012
• 卷：21
• 期：3
• 页码：389-393
• 文件大小：196 K

摘要

Purpose

We performed a meta-analysis of Phase III randomized trials to compare treatment outcomes for early-stage breast cancer patients receiving adjuvant chemotherapy with sequential or concurrent anthracyclines and taxanes.

Methods

All Phase III randomized trials comparing adjuvant chemotherapy of sequential or concurrent anthracyclines and taxanes in early-stage breast cancer patients were considered eligible. A total of three trials that enrolled 8728 women were analyzed. A pooled analysis was accomplished and event-based risk ratios (RR) with 95%confidence intervals (95%CI) were derived. The significant differences in disease-free survival (DFS) and overall survival (OS) were explored. A heterogeneity test was applied as well.

Results

Among three eligible trials, significant differences in favor of sequential regimen were seen in DFS (RR: 0.90; 95%CI: 0.84 to 0.98; P聽=聽0.01) and in OS (RR: 0.88; 95%CI: 0.79 to 0.98; P聽=聽0.02).

Conclusion

Considering all the available Phase III trials, sequential adjuvant chemotherapy for early breast cancer seems to add a significant benefit in both DFS and OS over concurrent regimens.