Activity-dependent neuroprotector homeobox protein level in Alzheimer's disease in Taiwanese

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• 作者：Yu-Fen Lin^a ; ^&dagger ; ; Ming-Hui Yang^b ; ^&dagger ; ; Yuan-Han Yang^c ; Wen-Cheng Chen^d ; Chi-Yu Lu^e ; Chien-Fang Peng^a ; Shiang-Bin Jong^f ; Li-Jhen Chen^f ; Shyh-Jong Wu^a ; Pei-Yu Chu^a ; Tze-Wen Chung^b ; Yu-Chang Tyan^f ; ^g ; ^h ; ^{yctyan@kmu.edu.tw}
• 关键词：activity-dependent neuroprotector homeobox protein ; Alzheimer's disease ; biomarker ; mass spectrometry ; proteomics
• 刊名：Genomic Medicine ; Biomarkers ; and Health Sciences
• 出版年：2012
• 期刊代码：pca172_22114254
• 类别：med
• 出版时间：March-June, 2012
• 卷：4
• 期：1-2
• 页码：48-50
• 文件大小：246 K

摘要

Alzheimer's disease (AD) is the most common cause of dementia of late life. The aim of this study was to utilize the proteomic approaches to establish serum protein patterns of AD. By using nano-high-performance liquid chromatography/electrospray ionization tandem mass spectrometry followed by peptide fragmentation pattern software to analyze proteome in human serum, the activity-dependent neuroprotector homeobox protein was found to exhibit significant differential expression compared with the control group and was confirmed by Western blotting and enzyme-linked immunosorbent assay. It may play an important role in slowing the progression of clinical symptoms of AD.