Protein kinase C isoforms during the development of deciduomata in pregnant rats
- 作者：Shyu ; Jyh-Cherng ; Hsieh ; Yih-Shou ; Chang ; Chen-Lurng ; Tsai ; Chin-Chiu ; Liu ; Hui-Chen ; Chang ; Ai-Chi ; et. al.
- 关键词：protein kinase C ; deciduomata ; pregnant rats
- 刊名：Life Sciences
- 出版年：1999
- 期刊代码：62_00243205
- 类别：imm
- 出版时间：May 14, 1999
- 卷：64
- 期：25
- 页码：2367-2373
- 文件大小：349 K
摘要
In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC 
was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC ζ was not down-modulated. It was increased both in the cytosolic and particulate fractions of the deciduomata, and paralleled the frequency of decidual cell mitosis. The other PKC isoform of δ was also increased, but it was associated with the cell regression. Therefore, these findings confirmed that the variable expression of PKC isoforms in decidualizing tissue may be involved in the modulation of decidual cell growth.
was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC ζ was not down-modulated. It was increased both in the cytosolic and particulate fractions of the deciduomata, and paralleled the frequency of decidual cell mitosis. The other PKC isoform of δ was also increased, but it was associated with the cell regression. Therefore, these findings confirmed that the variable expression of PKC isoforms in decidualizing tissue may be involved in the modulation of decidual cell growth.