Impact of pretreatment thrombocytosis on blood-borne metastasis and prognosis of gastric cancer

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• 作者：S.G. Hwang^a ; K.M. Kim^a ; J.H. Cheong ; ^{jhcheong@yuhs.ac} ; H.I. Kim ; J.Y. An ; W.J. Hyung ; S.H. Noh
• 关键词：Stomach neoplasm ; Blood platelets ; Thrombocytosis ; Prognosis ; Recurrence ; Neoplasm metastasis
• 刊名：European Journal of Surgical Oncology (EJSO)
• 出版年：2012
• 期刊代码：121_07487983
• 类别：med
• 出版时间：July, 2012
• 卷：38
• 期：7
• 页码：562-567
• 文件大小：209 K

摘要

Background

Thrombocytosis has been associated with malignancies and poor prognostic implications in cancer patients. In the present study the prognostic significance of pretreatment platelet (PLT) level was assessed with regard to recurrence and survival in patients with primary gastric adenocarcinoma.

Methods

The authors reviewed the prospective data of 1593 gastric cancer patients who received curative gastrectomy with extended lymphadenectomy. The correlations of PLT level with recurrence and overall survival were evaluated by both univariate and multivariate analyses.

Results

Thrombocytosis (鈮?0聽脳聽10⁴/渭L), present in 6.4%of the patients prior to curative surgery, was more frequently associated with advanced T and N classification, larger tumor size, anemia, and leukocytosis (p聽<聽0.05). In patients with pretreatment thrombocytosis compared to those without it, five-year survival rate was worse (56.9%vs. 65.5%; p聽=聽0.043), and recurrence rate was higher mainly due to the frequent hematogenous spread (51.0%vs. 34.5%; p聽<聽0.001). Furthermore, risk of blood-borne metastasis was almost three-fold higher in patients with pretreatment thrombocytosis (Odds ratio 2.83 [95%CI 1.67-4.77], p聽<聽0.001).

Conclusions

Pretreatment thrombocytosis correlated significantly with poor prognosis and can be used as an independent predictor of recurrence by blood-borne metastasis in gastric cancer.