Enhanced anti-Shigella activity of erythromycin supplemented with sulfadiazine

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• 作者：Honma ; Yasuko ; Sasakawa ; Chihiro ; Tsuji ; Takao ; Iwanaga ; Masaaki
• 关键词：Erythromycin ; Sulfadiazine ; Type III secretion ; Shigella
• 刊名：FEMS Immunology and Medical Microbiology
• 出版年：2001
• 期刊代码：32_09288244
• 类别：imm
• 出版时间：December, 2001
• 卷：32
• 期：1
• 页码：43-46
• 文件大小：232 K

摘要

Sulfadiazine enhanced the anti-Shigella activity of erythromycin. Erythromycin passes through the type III secretion apparatus and suppresses the growth of invasive Shigella organisms. Sulfadiazine enhanced this effect at the concentration under minimum inhibitory concentration and it came from not only the folate-inhibiting activity but also from a new function. It has proved that sulfadiazine stimulated type III secretion in Shigella as determined from the secretion of the pathogenic protein IpaB. As Congo red induced secretion of Ipa proteins and uptake of erythromycin through the type III secretion gate, sulfadiazine which is similar to Congo red in chemical structure may induce the uptake in the same way.