- 作者：Electra Nicolaidou ; MD ; PhD ; electra.nicol@gmail.com ; Christina Antoniou ; MD ; PhD ; Alexandra Miniati ; MD ; Eirini Lagogianni ; MD ; Athina Matekovits ; MD ; Alex Stratigos ; MD ; PhD ; Andreas Katsambas ; MD ; PhD
- 关键词：childhood vitiligo ; clinical presentation ; epidemiology ; thyroid disease
- 刊名：Journal of the American Academy of Dermatology
- 出版年：2012
- 期刊代码：200_01909622
- 类别：med
- 出版时间：June, 2012
- 卷：66
- 期：6
- 页码：954-958
- 文件大小：100 K
Background
Vitiligo onset during childhood is common. There are limited data regarding childhood-onset vitiligo.Objective
We sought to provide an epidemiologic and clinical comparison between childhood- and later-onset vitiligo.
Methods
Two groups of patients were included in this cross-sectional study. Consecutive patients examined at the Vitiligo Clinic of Andreas Sygros Hospital for Skin and Venereal Diseases, Athens, Greece, from January 2005 to December 2009 with a disease onset before the age of 12 years were included in the childhood-onset group. The later-onset group included randomly selected patients who were examined at the same period and had a disease onset after the age of 12 years. After clinical examination, a standardized questionnaire was completed for each patient.
Results
In all, 126 patients were included in the childhood-onset and 107 patients in the later-onset group. Childhood-onset vitiligo: (1) involved different sites at initial presentation, (2) included more cases of segmental type, and (3) was characterized by a higher prevalence of allergic diseases and a lower prevalence of thyroid diseases. Longer duration of disease and a positive family history of thyroid disease were associated with the presence of thyroid disease only in the childhood-onset group. In the later-onset group, only female sex was associated with the presence of thyroid disease.
Limitations
The study was conducted in a hospital specializing in skin diseases and a selection bias toward more severe vitiligo cases is possible.
Conclusions
Childhood-onset vitiligo had distinct epidemiologic and clinical characteristics, compared with later-onset disease.