A novel class of selective anti-Helicobacter pylori agents 2-oxo-2H-chromene-3-carboxamide derivatives
- 作者：Franco Chimenti ; Bruna Bizzarri ; Adriana Bolasco ; Daniela Secci ; Paola Chimenti ; Simone Carradori ; Arianna Granese ; Daniela Rivanera ; Daniela Lilli ; Aless ; ra Zicari ; et al.
- 关键词：Anti-Helicobacter pylori activity ; Coumarins
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 June 2007
- 卷：17
- 期：11
- 页码：3065-3071
- 文件大小：156 K
摘要
A novel class of selective anti-Helicobacter pylori agents, 2-oxo-2H-chromene-3-carboxamide derivatives, were prepared and evaluated for their anti-bacterial activity. All synthesized compounds showed little or no activity against different species of Gram-positive and Gram-negative bacteria and against various strains of pathogenic fungi. Some of them exhibited a potent and specific inhibitory effect on the growth of H. pylori, including metronidazole-resistant strains, in the 0.0039–16 μg/mL MIC range. A cytotoxic screening by the Trypan blue dye exclusion assay was also carried out on the most active compounds as anti-H. pylori agents. Among the derivatives examined for their cytotoxic potential, a number of them induced low cytotoxic effects.