Comparison of serologic responses to vaccination with one dose or two doses of 7-valent pneumococcal conjugate vaccine in HIV-infected adult patients

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• 作者：Ching-Lan Lu^a ; Chien-Ching Hung^b ; ^{hcc0401@ntu.edu.tw} ; Yu-Chung Chuang^b ; Wen-Chun Liu^b ; Chun-Ting Su^c ; Chin-Fu Hsiao^d ; Yu-Tzu Tseng^e ; Yi-Ching Su^c ; Shu-Fang Chang^c ; Sui-Yuan Chang^c ; ^f ; ^{sychang@ntu.edu.tw} ; Shan-Chwen Chang^b
• 关键词：Streptococcus pneumoniae ; Pneumococcal conjugate vaccine ; HIV infection ; Immunogenicity ; Combination antiretroviral therapy
• 刊名：Vaccine
• 出版年：2012
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：21 May, 2012
• 卷：30
• 期：24
• 页码：3526-3533
• 文件大小：819 K

摘要

Background

Vaccination with 7-valent pneumococcal conjugate vaccine (PCV) has been shown to decrease the incidence of recurrent invasive pneumococcal disease among HIV-infected adults in Africa. Longitudinal follow-up studies of serologic responses to different doses of 7-valent PCV are rarely performed in HIV-infected adult patients receiving combination antiretroviral therapy (cART).

Methods

From October 2008 to June 2010, 115 CD4-matched pairs of HIV-infected patients aged 鈮?0 years who had no prior pneumococcal vaccination received one or two doses of 7-valent PCV. Anticapsular antibodies against 4 serotypes (6B, 14, 19F, and 23F) were examined at the 12th, 24th, 36th, and 48th week following vaccination. Significant antibody responses were defined as 鈮?-fold increase in the IgG level plus a post-vaccination antibody level 鈮?000 ng/ml.

Results

The most common reported adverse effects were injection site soreness (19.3%) and pain (4.8%). Significant antibody response rate was highest for serotype 14, followed by 23F, 19F, and 6B in all of the four time points examined. At week 48, patients who received two doses of 7-valent PCV had a significantly higher response rate to serotype 6B (P = 0.03) and 23F (P = 0.01) than those who received one dose; moreover, the former group also had a higher response rate to at least one (P = 0.03) and two serotypes (P = 0.02) in intention-to-treat analysis than the latter group.

Conclusions

HIV-infected adult patients on cART who received two doses of 7-valent PCV achieved better serological responses to at least one serotype than those who received one dose during the 48 weeks of follow-up.