One-Pot Four-Component Dakin-West Synthesis of 尾-Acetamido Ketones Catalyzed by a Vanadium-Substituted Heteropolyacid

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• 作者：Reza TAYEBEE ; ^{rtayebee@yahoo.com} ; Shima TIZABI
• 关键词：homogeneous catalysis ; heteropolyacid ; Keggin ; Wells-Dawson ; Dakin-West ; 尾-acetamido ketone
• 刊名：Chinese Journal of Catalysis
• 出版年：2012
• 期刊代码：3_18722067
• 类别：ce
• 出版时间：April-June, 2012
• 卷：33
• 期：4-6
• 页码：923-932
• 文件大小：203 K

摘要

The multicomponent condensation of an aryl aldehyde, acetyl chloride, acetonitrile, and enolizable ketone as one-pot synthesis of 尾-acetamido ketones in high yields was investigated using commercial, non-corrosive, and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts. The best catalyst was H₅PW₁₀V₂O₄₀. The methodology used simple experimental conditions, and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of 尾-acetamido ketones.