Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol

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• 作者：Yih-Hsin Chang^a ; Chien-Ning Huang^b ; ^c ; Ming-Yuh Shiau^d ; ^{ming@sunrise.hk.edu.tw}
• 关键词：BMI ; body mass index ; BUN ; blood urea nitrogen ; CRE ; creatinine ; HDL-C ; high density lipoprotein-cholesterol ; IL-4 ; interleukin-4 ; IL-4R ; IL-4 receptor ; IL-4R伪 ; interleukin-4 receptor 伪 chain ; LDL ; low density lipoproteins ; PCR ; polymerase chain reactio
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：August, 2012
• 卷：59
• 期：2
• 页码：309-312
• 文件大小：179 K

摘要

The aim of this study is to investigate the correlation between E400A polymorphisms of interleukin-4 receptor 伪 chain (IL-4R伪) and lipid metabolism. Genomic DNA from 121 type 2 diabetes mellitus (T2DM) patients and 113 non-diabetic, non-obese control study subjects were extracted, and their IL-4R伪 E400A polymorphisms were analyzed by PCR-RFLP. The correlation between IL-4R伪 E400A genotypes and study subjects鈥?lipid profile was then examined. Significant associations of the IL-4R伪 E400A genotypes and high density lipoprotein-cholesterol (HDL-C) levels among control individuals (p = 0.007), as well as among the T2DM patients (p = 0.029), were observed. Significant correlations between IL-4R伪 E400A genotypes with blood pressure, as well as with blood urea nitrogen, were also observed in control subjects. Our results reveal that IL-4R伪 may play certain roles in the lipid metabolism of Taiwanese population and suggest a novel link between lipid metabolism and the cytokine receptor.