Wide linear-range detecting high sensitivity cholesterol biosensors based on aspect-ratio controlled ZnO nanorods grown on silver electrodes

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• 作者：Rafiq Ahmad^a  ; [Author Vitae] ; N. Tripathy^a  ; [Author Vitae] ; Yoon-Bong Hahn^a ; ^b ; ^{ybhahn@chonbuk.ac.kr}  ; [Author Vitae]
• 关键词：ZnO nanorods ; Aspect ratio ; Cholesterol oxidase ; Cholesterol biosensor ; Enzyme immobilization
• 刊名：Sensors and Actuators B ; Chemical
• 出版年：2012
• 期刊代码：161_09254005
• 类别：et
• 出版时间：5 July, 2012
• 卷：169
• 期：Complete
• 页码：382-386
• 文件大小：647 K

摘要

We have fabricated highly sensitive and wide linear-range detecting cholesterol biosensors based on zinc oxide nanorods (ZnO NRS). We report, for the first time, the use of aspect-ratio (AR) controlled ZnO NRs grown directly on silver (Ag) electrodes in solution at 90 掳C for the fabrication of cholesterol biosensors. More immobilization of enzymes and faster electron conduction with larger AR ZnO NRs were obtained. The biosensor with AR = 60 ZnO NRs exhibits a high reproducible sensitivity of 74.10 渭A/mM/cm², a wide linear range up to 16.0 mM, and a fast response time less than 2 s, which is the best reported to date for cholesterol biosensors using ZnO nanostructures. Furthermore, the fabricated biosensors show an excellent anti-interference ability against electroactive species such as glucose, ascorbic acid, l-cysteine, and uric acid.