Load application induces changes in the expression levels of Sox-9, FGFR-3 and VEGF in condylar chondrocytes
- 作者：Alex ; ra K. Papadopoulou ; Dionysios J. Papachristou ; Stavros A. Chatzopoulos ; Pertti Pirttiniemi ; Athanasios G. Papavassiliou ; Efthimia K. Basdra
- 关键词：Cartilage tissue ; Condylar chondrocytes ; Mechanical load ; Sox-9 ; FGF receptor 3 ; Vascular endothelial growth factor
- 刊名：FEBS Letters
- 出版年：2007
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：15 May 2007
- 卷：581
- 期：10
- 页码：2041-2046
- 文件大小：1030 K
摘要
Experimental and clinical observations have proven the modulatory effects of mechanical loading on the development and maintenance of cartilage architecture. Here we examined the involvement of Sox-9, FGFR-3 and VEGF (pivotal factors controlling cartilage development and growth) in the mechano-transduction pathway of mandibular condylar cartilage by changing the dynamics of the transmitted load via changes in food hardness. To this end, condyle cartilage tissue of rats fed with hard or soft food was analyzed immunohistochemically at various time points. Our findings demonstrate that different mechanical loading conditions in condylar chondrocytes trigger differentiation-/maturation-related processes by affecting the expression levels of these factors, ultimately influencing condylar cartilage growth.