Accelerated Hyperfractionated Radiotherapy for Cervical Cancer: Multi-Institutional Prospective Study of Forum for Nuclear Cooperation in Asia Among Eight Asian Countries
- 作者：Tatsuya Ohno ; Takashi Nakano ; Shingo Kato ; Cho Chul Koo ; Yaowalak Chansilpa ; Pittayapoom Pattaranutaporn ; Miriam Joy C. Calaguas ; Rey H. de los Reyes ; Beibei Zhou ; Juying Zhou ; Raden Susworo ; Nana Sup
- 关键词：Radiotherapy ; Accelerated hyperfractionation ; Cervical cancer ; Developing country ; Overall treatment time
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2008
- 期刊代码：136_03603016
- 类别：med
- 出版时间：1 April 2008
- 卷：70
- 期：5
- 页码：1522-1529
- 文件大小：194 K
摘要
The enantioselective total synthesis of callipeltoside A is described. Two syntheses of the macrolactone subunit are included: the first relies upon an Ireland–Claisen rearrangement to generate the trisubstituted olefin geometry and the second utilizes an enantioselective vinylogous aldol reaction for this purpose. Enantioselective syntheses of the sugar and chlorocyclopropane side chain fragments are also disclosed. The relative and absolute stereochemistry of this natural product was determined by fragment coupling with the two enantiomers of the side chain fragment.