Intravitreal administration of bevacizumab in the treatment of choroidal metastasis in a patient with erlotinib-failed pulmonary adenocarcinoma

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• 作者：Chun-Liang Lai^a ; ^b ; Kuo-Sheng Fan^a ; Yen-Hsien Lee^a ; ^b ; Hsing-Chun Chen^a ; Wen-Hsiung Fan^c ; ^{wenshuangf@yahoo.com.tw}
• 关键词：Choroidal ; Metastasis ; Lung ; Bevacizumab ; Intravitreal
• 刊名：Lung Cancer
• 出版年：2012
• 期刊代码：187_01695002
• 类别：med
• 出版时间：June, 2012
• 卷：76
• 期：3
• 页码：496-498
• 文件大小：366 K

摘要

Choroidal metastasis is uncommon and usually identified in a relatively advanced cancer status. The median survival after diagnosing choroid metastasis in lung cancer patients was only 1.9 months. Once failed to systemic treatment, there was no effective local treatment for saving visual acuity. The off-label use of intravitreal bevacizumab was popular in treating VEGF-mediated chorioretinal diseases worldwide. We here demonstrate a dramatic and durable response to intravitreal bevacizumab. Unlike the previous similar reports, our patient had failed both first- and second-line therapies.