Malnutrition enhances cardiovascular responses to chemoreflex activation in awake rats

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• 作者：Arlete Rita Penitente ; Luciano Gon&#xe7 ; alves Fern ; es ; Leonardo M&#xe1 ; ximo Cardoso ; Marcelo Eust&#xe1 ; quio Silva ; Maria Lú ; cia Pedrosa ; Antô ; nio Leite Silva ; Andr&#xe9 ; a Siqueira Haibara ; M&#
• 关键词：Arterial pressure ; Chemoreflex ; Albumin ; Sympathetic activity ; Low-protein diet
• 刊名：Life Sciences
• 出版年：2007
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：26 July 2007
• 卷：81
• 期：7
• 页码：609-614
• 文件大小：211 K

摘要

Several studies in the literature suggest that low-protein intake is associated with increases in sympathetic efferent activity and cardiovascular disease. Among the possible mechanisms, changes in the neurotransmission of cardiovascular reflexes have been implicated. Therefore, the present study comprised the evaluation of chemoreflex responsiveness in rats subjected to a low-protein diet during the 35 days after weaning. As a result, we observed that malnourished rats presented higher levels of baseline mean arterial pressure and heart rate and exhibited a mild increase in the pressor response to chemoreflex activation. They also exhibited a massive bradycardic response to chemoreflex activation. Interestingly, bilateral ligature of the carotid body arteries further increased baseline mean arterial pressure and heart rate in malnourished animals. The data suggest severe autonomic imbalance and/or change in the central interplay between neural and cardiovascular mechanisms.