Ganglioglioma with anaplastic recurrence of the neuronal element following radiotherapy

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• 作者：Andrew Tarnaris ; Ciaran O&#x2019 ; Brien ; Robert M. Redfern
• 关键词：Ganglioglioma ; Neuroblastoma ; Radiotherapy
• 刊名：Clinical Neurology and Neurosurgery
• 出版年：2006
• 期刊代码：60_03038467
• 类别：med
• 出版时间：December 2006
• 卷：108
• 期：8
• 页码：761-767
• 文件大小：2050 K

摘要

Gangliogliomas are rare tumours in adults representing between 0.5%and 1%of all neuroepithelial tumours. They are of mixed cellularity comprised both of a neuronal and a glial population. Although malignant transformation is rare, and this mostly occurs in the glial element, we present a case of malignant neuroblastomatous transformation of a ganglioglioma. This is only the second ever case to our knowledge in the literature reporting the participation of the neuronal element in the malignant transformation of a ganglioglioma. In contrast with the previous published case, our patient has received post-operative therapeutic radiotherapy. The related literature is reviewed and the oncogenic role of therapeutic irradiation is discussed.