Cinnamic acid as one of the antidiabetic active principle(s) from the seeds of Syzygium alternifolium
- 作者：Ramesh Babu Kasetti ; Shaik Abdul Nabi ; Sirasangandla Swapna ; Chippada Apparao ; chippadar@yahoo.com
- 关键词：Bioassay-guided fractionation ; Carbohydrate metabolism ; Cinnamic acid ; Streptozotocin ; Syzygium alternifolium
- 刊名：Food and Chemical Toxicology
- 出版年：2012
- 期刊代码：20_02786915
- 类别：pha
- 出版时间：May, 2012
- 卷：50
- 期：5
- 页码：1425-1431
- 文件大小：641 K
摘要
The Indian traditional system of medicine prescribed plant therapies for diseases including diabetes mellitus. One such plant is Syzygium alternifolium (SA). We reported earlier, that fraction C from aqueous extract of SA seeds showed good antihyperglycemic and antihyperlipidemic activities. In continuation to it, we have performed bioassay guided fractionation of fraction C and identified cinnamic acid as a component with antihyperglycemic activity. A detailed study was undertaken to elucidate its mode of antidiabetic action by giving fraction C (50 mg/kg b.w) orally, once a day for 30 days in STZ induced diabetic rats. The altered enzyme activities of carbohydrate metabolism in liver and kidney of diabetic rats were significantly (p < 0.01) reverted to near normal levels by the administration of fraction C. Fraction C lowered blood glucose as expected, immediately following treatment, and led to glibenclamide-like modulatory effects on enzyme activities related to glucose homeostasis after 30 days treatment, indicating that cinnamic acid may prove useful in diabetes management.