In 42 patients 50.0 mo (median; range 17.1-100.6) after LTX and 30 patients 93.0 mo (31.2-180.1) after KTX as wells as in LCI (n = 39) or HD (n = 10) patients mid-arm muscle and fat area, body cell mass, and phase angle (bioimpedance analysis), and resting energy expenditure (indirect calorimetry, REECALO) were measured.
Obesity was more prevalent in LTX (17%) than LCI (3%) and in KTX (27%) than in HD (10%). In LTX and KTX, phase angle was higher than in end-stage disease (LTX 5.6掳 [4.1-7.2] versus LCI 4.4掳 [2.9-7.3], P < 0.001; KTX 5.9掳 [4.4-8.7] versus HD 4.3掳 [2.9-6.8]) but was lower in all patient groups than in controls (7.1掳; 4.6-8.9; P < 0.001). In LCI and HD REECALO was higher than predicted, while in LTX and KTX REECALO was not different from predicted REE.
Despite excellent graft function, many long-term LTX or KTX survivors exhibit a phenotype of sarcopenic obesity with increased fat but low muscle mass. This abnormal body composition is observed despite normalization of the hypermetabolism found in chronic disease and cannot be explained by overeating. The role of appropriate nutrition and physiotherapy after transplantation merits further investigation.