Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth

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• 作者：Hiroaki Okuda ; Shingo Miyata ; Yasutake Mori ; Masaya Tohyama
• 关键词：Cortical neuron ; Neurite outgrowth ; PCP gene ; Postmitotic neuron ; Prickle
• 刊名：FEBS Letters
• 出版年：2007
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：2 October 2007
• 卷：581
• 期：24
• 页码：4754-4760
• 文件大小：530 K

摘要

The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development.