Increased hypothalamic angiotensin-(1–7) levels in rats with aortic coarctation-induced hypertension
- 作者：Mariela M. Gironacci ; K. Bridget Brosnihan ; Carlos M. Ferrario ; Susana Gorzalczany ; Marí ; a A. Lopez Verrilli ; Mariano Pascual ; Carlos Taira ; Clara Peñ ; a
- 关键词：Angiotensin II ; Angiotensin-(1– ; 7) ; Aortic coarctation ; Hypertensive rats ; Tissue levels ; Plasma levels ; Hypothalamus
- 刊名：Peptides
- 出版年：2007
- 期刊代码：59_01969781
- 类别：neu
- 出版时间：August 2007
- 卷：28
- 期：8
- 页码：1580-1585
- 文件大小：210 K
摘要
Since angiotensin (Ang) (1–7) injected into the brain blocked Ang II pressor actions in rats made hypertensive by aortic coarctation (CH), we examined systemic and tissue angiotensin peptide levels, specifically concentrating on the hypothalamic Ang-(1–7) levels. Plasma, heart and kidney isolated from CH rats showed increased levels of Ang I, Ang II and Ang-(1–7) compared with the normotensive group, with Ang II being the predominant peptide in heart and kidney. In the hypothalamus, equimolar amounts of Ang II and Ang-(1–7) were found in the sham group, whereas only Ang-(1–7) levels increased in CH rats. We conclude that aortic coarctation activates systemic and tissue renin–angiotensin system. The increased central levels of Ang-(1–7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process.