Cancer classification by gradient LDA technique using microarray gene expression data
- 作者：Alok Sharma ; Kuldip K. Paliwal
- 关键词：DNA microarray ; Linear discriminant analysis (LDA) ; Gradient LDA (GLDA) ; Dimensionality reduction ; Cancer classification ; Feature selection ; Feature extraction
- 刊名：Data and Knowledge Engineering
- 出版年：2008
- 期刊代码：44_0169023x
- 类别：cp
- 出版时间：August 2008
- 卷：66
- 期：2
- 页码：338-347
- 文件大小：269 K
摘要
Cancer classification is one of the major applications of the microarray technology. When standard machine learning techniques are applied for cancer classification, they face the small sample size (SSS) problem of gene expression data. The SSS problem is inherited from large dimensionality of the feature space (due to large number of genes) compared to the small number of samples available. In order to overcome the SSS problem, the dimensionality of the feature space is reduced either through feature selection or through feature extraction. Linear discriminant analysis (LDA) is a well-known technique for feature extraction-based dimensionality reduction. However, this technique cannot be applied for cancer classification because of the singularity of the within-class scatter matrix due to the SSS problem. In this paper, we use Gradient LDA technique which avoids the singularity problem associated with the within-class scatter matrix and shown its usefulness for cancer classification. The technique is applied on three gene expression datasets; namely, acute leukemia, small round blue-cell tumour (SRBCT) and lung adenocarcinoma. This technique achieves lower misclassification error as compared to several other previous techniques.