Crosstalk between xenobiotics metabolism and circadian clock
- 作者：Thierry Claudel ; Gaspard Cretenet ; Anne Saumet ; Fré ; dé ; ric Gachon
- 关键词：Circadian rhythms ; PARbZip transcription factors ; Detoxification ; Liver metabolism
- 刊名：FEBS Letters
- 出版年：2007
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：31 July 2007
- 卷：581
- 期：19
- 页码：3626-3633
- 文件大小：370 K
摘要
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.