ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes

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• 作者：Lucí ; a Otero ; Christian Folch ; Germá ; n Barriga ; Carolina Rigol ; Lucia Opazo ; Marisol Vieites ; Dinorah Gambino ; Hugo Cerecetto ; Ester Norambuena ; Claudio Olea-Azar
• 关键词：ESR ; Chagas ; Pd complex ; ORAC ; Cyclic voltammetry
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2008
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：August 2008
• 卷：70
• 期：3
• 页码：519-523
• 文件大小：332 K

摘要

Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen palladium complexes grouped in two series of the formula [PdCl₂HL] or [PdL₂] were studied. ESR spectra of the free radicals obtained by electrolytic reduction were characterized and analyzed. The ESR spectra showed two different hyperfine patterns. The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however we observed great differences between 5-nitrofurane and 5-nitrofurylacroleine derivatives. The scavenger properties of this family of compounds were lower than Trolox.