Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives
- 作者：Jorge Rodrí ; guez ; Claudio Olea-Azar ; German Barriga ; Christian Folch ; Alej ; ra Gerpe ; Hugo Cerecetto ; Mercedes Gonzá ; lez
- 关键词：5-Nitroindazole ; Cyclic voltammetry ; ESR ; Trypanosoma cruzi
- 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
- 出版年：2008
- 期刊代码：99_13861425
- 类别：ch
- 出版时间：August 2008
- 卷：70
- 期：3
- 页码：557-563
- 文件大小：772 K
摘要
Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[ω-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the protonation of the nitro group was observed. The reactivity of the nitro-anion radical for these derivatives with glutathione, a biological relevant thiol, was also studied by cyclic voltammetry. These studies demonstrated that glutathione could react with radical species from 5-nitroindazole system. Also we demonstrated that nitro-anion radicals show three different patterns of delocalization where the indazole 1-lateral chain does not have major influence.