The clinical significance of autoantibodies directed against prothrombin in primary antiphospholipid syndrome

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• 作者：A. Hoxha^a ; ^{arielahoxha@hotmail.com} ; A. Ruffatti^a ; M. Pittoni^b ; A. Bontadi^a ; M. Tonello^a ; E. Salvan^a ; M. Plebani^b ; L. Punzi^a
• 关键词：Antiphospholipid syndrome ; Antiphospholipid antibodies ; Anti-prothrombin antibodies
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 期刊代码：54_00098981
• 类别：med
• 出版时间：18 May, 2012
• 卷：413
• 期：9-10
• 页码：911-913
• 文件大小：266 K

摘要

Background

To evaluate the clinical significance of IgG/IgM antibodies directed against prothrombin (PT) in a homogeneous cohort of patients with primary APS (PAPS).

Methods

IgG/IgM anti-prothrombin (aPT) antibodies were measured using a commercial ELISA kit in 158 PAPS patients and in 214 control subjects (100 healthy blood donors and 114 patients with autoimmune diseases).

Results

IgG/IgM aPT antibodies were significantly associated with PAPS (OR, 95%CI: 52.0, 7.0-385.5; 9.8, 1.2-80.8, respectively). They were found to have a high specificity (IgG 99.50%, IgM 99.54%) but a low sensitivity (IgG 19.60%, IgM 3.80%) for PAPS. IgG aPT antibodies were significantly higher in the PAPS patients with thrombosis (OR, 95%CI: 69.2, 9.2-519.1) as well as in those with pregnancy morbidity alone (OR, 95%CI: 20.5, 2.4-174.5). The prevalence of IgG aPT was not significantly different in the thrombotic and obstetric patients, and the presence of IgM aPT antibodies was significant only in patients with thrombosis (OR, 95%CI: 2.6, 1.6-110.8).

Conclusions

The study's findings confirm that IgG/IgM aPT antibodies are significantly associated with PAPS and indicate that IgG aPT antibodies are associated with clinical subsets of the disease. For the time being, however, the lower sensitivity of IgG/IgM antibodies with respect to conventional aPL antibodies precludes their inclusion in the recommendations for the diagnosis of PAPS.