Variance-penalized response-adaptive randomization with mismeasurement

详细信息	查看全文 | 推荐本文 |

• 作者：Xuan Li ; ^{umlix2@yahoo.ca} ; ^{xuan_li@umanitoba.ca} ; Xikui Wang¹ ; ^{xikui_wang@umanitoba.ca}
• 关键词：Clinical trials ; Response-adaptive designs ; Misclassification ; Variance-penalized criterion ; Power
• 刊名：Journal of Statistical Planning and Inference
• 出版年：2012
• 期刊代码：36_03783758
• 类别：mt
• 出版时间：July, 2012
• 卷：142
• 期：7
• 页码：2128-2135
• 文件大小：217 K

摘要

We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.