Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome
- 作者：Hwu ; Y.M. ; Lin ; S.Y. ; Huang ; W.Y. ; Lin ; M.H. ; Lee ; R.K.K.
- 关键词：Clomiphene citrate-resistant polycystic ovary syndrome ; Metfomin pretreatment ; Ovulation rate ; Pregnancy rate
- 刊名：International Journal of Gynecology and Obstetrics
- 出版年：2005
- 期刊代码：130_00207292
- 类别：med
- 出版时间：July, 2005
- 卷：90
- 期：1
- 页码：39-43
- 文件大小：103 K
摘要
Objective: To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS). Method: Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment. Results: In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026). Conclusion: Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.