• 作者：Á ; lvaro Girá ; ldez Gallego^a ; ^{giraldezg@hotmail.com} ; José ; Manuel Sousa^a ; Juan Manuel Pascasio^a ; Concepció ; n Prats^b ; Aurelio Cayuela^c ; Antonio Garrido^a
• 关键词：Model for End-Stage Liver Disease ; Child-Turcotte-Pugh ; Cociente internacional normalizado ; Trasplante hepá ; tico
• 刊名：Gastroenterolog铆a y Hepatolog铆a
• 出版年：2009
• 期刊代码：pca167_02105705
• 类别：med
• 出版时间：August-September 2009
• 卷：32
• 期：7
• 页码：465-471
• 文件大小：371 K

Objetive

To correlate blood coagulation factor levels with disease severity in cirrhotic patients evaluated as candidates for liver transplantation.

Material and method

We included 87 patients (75.9%men) with a mean age of 54卤9.4 years. Etiology and Child-Turcotte-Pugh (CTP) class were as follows: alcohol-related (36.8%), hepatitis C virus infection (35.6%), hepatitis B virus infection (11.5%) and other (16.1%); class A (13.8%), class B (40.2%) and class C (46%), respectively. The mean value of the Model for End-Stage Liver Disease (MELD) score was 14.5卤5.9. Levels of factors II, V, VII, VIII, IX and X were compared between each CTP grade and with the MELD score.

Results

Except for factor VIII, all the clotting factors were reduced in our series (in particular factors II, V and VII) and deficiencies in these factors were closely related to CTP grade with statistical significance for stage C (p<0.05). We also found a marked inverse correlation between the MELD score and factors II, V, VII, IX and X values (p<0.05).

Conclusions

A correlation was found between reduced levels of factors II, V, VII, IX and X in liver cirrhosis and the severity of liver disease.