Fatal varicella hepatitis in an asthmatic adult after short-term corticosteroid treatment
- 作者：Hervé ; Hyvernat ; Pierre-Marie Roger ; Cé ; cile Pereira ; Marie Christine Saint-Paul ; Fré ; dé ; ric Vandenbos and Gilles Bernardin
- 关键词：Chicken pox ; Acute hepatic failure ; Asthma ; Prednisone
- 刊名：European Journal of Internal Medicine
- 出版年：2005
- 期刊代码：91_09536205
- 类别：med
- 出版时间：2005
- 卷：16
- 期：5
- 页码：361-362
- 文件大小：67 K
摘要
A 28-year-old male patient, treated with prednisone for bronchitis with sibilant rales, developed fever with abdominal pain and generalized vesicular rash after coming in contact with varicella-infected children. He was hospitalized after having a seizure. Laboratory values revealed hepatitis and rapidly fulminant hepatic insufficiency with disseminated intravascular coagulation. Despite acyclovir treatment, the patient died 4 days after admission. Clinical presentation could evoke a Reye's syndrome, but liver biopsy showed massive coagulative necrosis. This report demonstrates the increased risk of complicated varicella associated with the use of corticosteroids, even for a short period of time.