Hyperthermie grave liée à un sevrage brutal de baclofène administré de façon continue par voie intrathécale
- 作者：Grenier ; B ; Mesli ; A ; Cales ; J ; Castel ; JP ; Maurette ; P
- 关键词：baclofen ; withdrawal syndrome ; hyperthermia ; rhabdomyolysis ; baclofè ; ne ; sevrage ; hyperthermie ; rhabdomyolyse
- 刊名：Annales Francaises d'Anesthesie et de Reanimation
- 出版年：1996
- 期刊代码：14_07507658
- 类别：med
- 出版时间：1996
- 卷：15
- 期：5
- 页码：659-662
- 文件大小：315 K
摘要
Severe hyperthermia after acute cessation of continuous intrathecal baclofen administration. Baclofen is used for the treatment of post-traumatic spasticity. It carries a risk of overdose as well as of an acute withdrawal syndrome. We report two cases of severe hypertonia and hyperthermia (> 42 °C), occurring after accidental discontinuation of intrathecal infusion of baclofen. Both hypertonia and hyperthermia ceased when administration of baclofen was resumed. In parallel, the patients developed transient life-threatening alterations of hepatic (cytolysis), haematologic (coagulopathy) and cardiorespiratory functions for some days. It is concluded that the occurrence of such a withdrawal syndrome should be prevented, especially in patients with chronic intrathecal administration and first symptoms should be recognized without delay. Relationships with other malignant hyperthermias are discussed.