摘要
Ring-closing iodoamination of (E)-configured, N-伪-methyl-p-methoxybenzyl protected homoallylic amines upon treatment with I2 and NaHCO3 in MeCN occurs with concomitant loss of the N-伪-methyl-p-methoxybenzyl group to give 3-iodopyrrolidines in >99:1 dr. This transformation was used as one of the key steps in the total asymmetric synthesis of (鈭?-codonopsinine, which was achieved in seven steps (from commercially available tert-butyl crotonate) in 5%overall yield and >99:1 dr.