Micronutrient special issue: Coenzyme Q₁₀ requirements for DNA damage prevention

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• 作者：Constance Schmelzer^a ; ^{schmelzer@fbn-dummerstorf.de} ; Frank Dö ; ring^b
• 关键词：Coenzyme Q10 ; Genomic stability ; DNA damage prevention ; Dietary supplement
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2012
• 期刊代码：115_00275107
• 类别：bio
• 出版时间：1 May, 2012
• 卷：733
• 期：1-2
• 页码：61-68
• 文件大小：281 K

摘要

Coenzyme Q₁₀ (CoQ₁₀) is an essential component for electron transport in the mitochondrial respiratory chain and serves as cofactor in several biological processes. The reduced form of CoQ₁₀ (ubiquinol, Q₁₀H₂) is an effective antioxidant in biological membranes. During the last years, particular interest has been grown on molecular effects of CoQ₁₀ supplementation on mechanisms related to DNA damage prevention. This review describes recent advances in our understanding about the impact of CoQ₁₀ on genomic stability in cells, animals and humans. With regard to several in vitro and in vivo studies, CoQ₁₀ provides protective effects on several markers of oxidative DNA damage and genomic stability. In comparison to the number of studies reporting preventive effects of CoQ₁₀ on oxidative stress biomarkers, CoQ₁₀ intervention studies in humans with a direct focus on markers of DNA damage are limited. Thus, more well-designed studies in healthy and disease populations with long-term follow up results are needed to substantiate the reported beneficial effects of CoQ₁₀ on prevention of DNA damage.