Complementary 伪-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone

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• 作者：Chris Limberakis ; ^{chris.limberakis@pfizer.com} ; Jianke Li ; Gayatri Balan ; David A. Griffith ; Daniel W. Kung ; Colin Rose ; Derek Vrieze
• 关键词：Spiro[pyrazolopyranpiperidine]ketone ; Enolate alkylation ; DMPU ; Aldol condensation ; 1 ; 4-Addition
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：16 May, 2012
• 卷：53
• 期：20
• 页码：2543-2547
• 文件大小：804 K

摘要

Complementary 伪-alkylation methods are used to derivatize a sterically hindered spiro[pyrazolopyranpiperidine]ketone. More specifically, enolate alkylations in the presence of DMPU and aldol condensations are employed to deliver these compounds.