Intracellular Ca²⁺ channels - A growing community

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• 作者：Colin W. Taylor ; ^{cwt1000@cam.ac.uk} ; Philippa Dale
• 关键词：IP3 receptor ; NAADP ; TPC ; Calcium channel ; Ryanodine receptor
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2012
• 期刊代码：109_03037207
• 类别：bio
• 出版时间：28 April, 2012
• 卷：353
• 期：1-2
• 页码：21-28
• 文件大小：419 K

摘要

The Ca²⁺ signals that control almost every cellular activity are generated by regulating Ca²⁺ transport, usually via Ca²⁺-permeable channels, across the plasma membrane or the membranes of intracellular organelles. The most widespread and best understood of the intracellular Ca²⁺ channels are inositol trisphosphate receptors (IP₃R) and ryanodine receptors, most of which are expressed in the endoplasmic or sarcoplasmic reticulum. However, accumulating evidence suggests physiological roles for many additional Ca²⁺ channels in both ER and other intracellular organelles. Interactions between these channels, whether mediated by Ca²⁺ itself or interactions between proteins, is a recurrent feature of the Ca²⁺ signals evoked by physiological stimuli. We focus on two specific examples, clustering of IP₃Rs and NAADP (nicotinic acid dinucleotide phosphate)-evoked Ca²⁺ release from endo-lysosomes, to illustrate the diversity of Ca²⁺ channels and the interplay between them.