• 作者：E. Reyna ; ^{sippenbauch@gmail.com} ; J. Mejia ; N. Reyna ; D. Torres ; J. Santos ; J. Perozo
• 关键词：Interferó ; n gamma ; Preeclampsia ; Citokinas
• 刊名：Cl铆nica e Investigaci贸n en Ginecolog铆a y Obstetricia
• 出版年：2012
• 期刊代码：pca89_0210573X
• 类别：med
• 出版时间：May-June, 2012
• 卷：39
• 期：3
• 页码：108-112
• 文件大小：254 K

Objective

To compare concentrations of interferon-gamma in patients with preeclampsia and healthy normotensive pregnant women.

Material And Methods

One hundred patients were selected. Fifty preeclamptic patients were selected as cases (group A) and 50 healthy pregnant women with a similar age and body mass index to patients in group A were selected as controls (group B). Blood samples for interferon-gamma determination were collected in all patients before labor and immediately after diagnosis in the study group.

Results

There were no significant differences in maternal age, gestational age or body mass index at sample collection (p=ns). Statistically significant differences were found between groups in mean values of systolic and diastolic blood pressure (p<0.05). Interferon-gamma concentrations were significantly higher in group A (75.5卤27.7 pg/ml) than in group B (54.2卤29.6 pg/ml, p<0.05) and there was a slight, positive and significant correlation with values of systolic blood pressure (r=0.383; p<0.05) and diastolic blood pressure (r=0.259; p<0.05).

Conclusion

Interferon-gamma concentrations were significantly higher in preeclamptic patients than in healthy normotensive pregnant women.